Action
- Non opioid analgesic
- It is centrally acting
- Exact mechanism is not known
- It has antimuscarinic and sympathomimetic activity
Adult Dose
Moderate acute and chronic pain
Oral
- Dose: 60mg PO
- Dose range: 30-90 mg tid
- Max: 300 mg daily
- Elderly: Initially 30 mg tid
Intramuscular
- Dose: 20mg IM every 6 hrly
Intravenous
- Dose: 20 mg slow IV inj every 4 hrs
- Max: 120 mg daily
∗Patient should be lying down while receiving inj and should remain so for 15-20 min
Special Condition
- Renal Impairment
- Hepatic impairment
- Lactation
- Pregnancy
Contraindication
- History of convulsive disorders
Side Effect
- Nausea
- Vomiting
- Sweating
- Drowsiness
- Insomnia
- Urinary retention
- Dizziness
- Hypotension
- Tremor
- Paresthesia
- Palpitations
- Nervousness
- Mental Confusion
- Blurred Vision
- Headache
- Dry Mouth
- Angioedema
- Tachycardia
- Euphoria
- Hallucinations
- Convulsions
- Temporary pink discolouration of the urine
Precaution
- Glaucoma, Urinary retention, Hepatic or renal impairment
- Pregnancy
Interaction
- Adverse effects increased with antimuscarinic or sympathomimetic drugs
- Increased risk of seizures with TCAs
- Increased CNS depressant effects with other sedatives
- Potentially Fatal
- Additive sympathomimetic effects with MAOIs.
