Action
- Analgesic, Antipyretics, Weak Anti Inflammatory
- Inhibition of Prostaglandin Synthesis in CNS.
Adult Dose
Mild to Moderate Pain, Fever & Headache
Dose : 500mg 4-6 hrly PO
Max : 8 tab/day (4 gm)
Intravenous
> 50 Kg
- Dose: 1g Bid-qid IV Infusion
- Infusion time: 15 min
- Max: 4g daily
33 to 50 Kg
- Dose: 15 mg/kg bid-qid IV infusion
- Infusion time: 15 min
- Max: 60 mg/kg/day
Child Dose
Mild to moderate Pain & Fever & Post -immunization pyrexia
Oral
- <3 Month : 40 mg
- 4-11 Month : 80 mg tid PO
- 1-2 year : 120 mg tid PO
- 2-3 Year : 160mg tid PO
- 4-5 Year : 240 mg tid PO
- 6-12 Year : 250-500 mg tid PO
Rectal Suppository
- 3 Months: 1 Year : 60-125 mg tid
- 1-5 Year: 125-250 mg tid
- 5-12 Years: 250-500 mg tid
- >12 Year: 500mg-1 g tid
- Max: 4 dose/day
Special Condition
- Renal Impairment
- Hepatic Impairment
- Lactation
- Pregnancy
Contraindication
- Hypersensitivity
Side Effect
- Thrombocytopenia
- Leucopenia
- Pancytopenia
- Neutropenia
- Agranulocytosis
- Pain and burning sensation at inj. site rarely
- Hypotension and Tachycardia
- Potentially Fatal: Stevens-Johnson Syndrome
- Toxic epidermal necrolysis
- Acute generalized exanthematous pustulosis
- Acute renal tubular necrosis and hepatotoxicity
Precaution
- Patient with chronic alcoholism, Known G6PD deficiency, severe hypovolemia, chronic malnutrition.
- Renal and hepatic impairment
- Pregnancy and Lactation
- Monitoring parameters Monitor serum paracetamol levels especially when acute overdose is suspected and with Longterm use.
Internation
- May reduce serum levels with anticonvulsants
- May enhance the anticoagulant effect of Warfarin and other coumarins with prolonged use
- Accelerated absorption with metoclopramide and domperidone
- May increase serum levels with probenecid
- may increase serum levels of chloramphenicol
- May reduce absorption with cholestyramine with in 1 hour of admin
- May cause severe hypothermia with phenothiazine.
