Action
Paracetamol
- Analgesic, Antipyresis, Weak Anti Inflammatory
- Inhibition of Prostaglandin Synthesis in CNS
Caffeine
- Methylxanthine
- Phosphodiesterase Inhibitor
- Antagonistic Effect
- CNS and resp stimulant
- Bronchodilating and diuretic properties
Adult Dose
Mild to moderate pain, Fever & Headache
Dose: 500mg 4-6 hrly PO
Max: 8 tab/day (4gm)
Child Dose
- <12 yrs: Avoid Use
- > 1-2 tblets every 4-6 hours
Max : 8 tablets daily
Special Condition
- Renal Impairment
- Hepatic Impairment
- Lactation
- Pregnancy
Contraindication
- Severe renal function impairment
- Severe hepatic disease
- Viral Hepatitis
- Hypersensitivity
Side Effect
- Hematological reactions including thrombocytopenia.
- Leucopenia
- Pancytopenia
- Neutropenia
- Agranulocytosis have been reported
- Skin Rashes
- restlessness
- Anxiety
- Irritability
- Headaches
- Gastrointestinal disturbances and palpitations
Precaution
- Use with caution in alcoholism, hepatic or renal disorder.
- The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.
- Excessive intake of caffeine should be avoided while taking this product.
Interaction
- May reduce serum levels with anticonvulsants
- May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use
- Accelerated absorption with metoclopramide and domperidone
- May increase serum levels with probenecid
- May increase serum levels of chloramphenicol
- May reduce absorption with cholestyramine within 1 hr of admin
- May cause severe hypothermia with phenothiazine
